Open Now

  • Mon
    11:30 am - 12:00 am

  • Tue
    11:30 am - 2:00 am

  • Wed
    11:30 am - 2:00 am

  • Thu
    11:30 am - 2:00 am

  • Fri
    11:30 am - 2:00 am

  • Sat
    11:30 am - 2:00 am

  • Sun
    12:00 pm - 12:00 am

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221 Main is a family restaurant & bar located in St. Joseph, MI 49085.

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